In 2011, styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a ‘poison scandal’ in the Danish media; but now a registry study of more than 72,000 employees from more than 400 companies that have been exposed to styrene during production of glassfibre reinforced plastics, has not found an increased incidence of a wide range of cancer … The Factors That Do Increase Cancer Risk. Teixeira et al. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. Moreover, in 2009 (1), the US Department of Health and Human Service’s NTP declared ‘Styrene is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity in humans, sufficient evidence of carcinogenicity in experimental animals, and supporting mechanistic data.’, NTP further affirms, regarding human studies (1), that: ‘The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) increased mortality from or incidence of cancer of the lymphohematopoietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. "But in the instance of styrene… The new announcement from the World Health Organisation will be published by IARC as a Monograph, authored by 23 handpicked researchers from around the world, including Professor Henrik Kolstad. Styrene officially linked to cancer . IARC’s (5) evaluation of the available human studies nearly 10 years ago stated ‘There is limited evidence in humans for the carcinogenicity of styrene’, which indicates evidence of a credible but not a clear demonstration of a causal association with lymphatic/hematopoietic neoplasms in humans. The most robust studies are a 2-year inhalation study in CD-1 mice and a 2-year oral gavage study in B6C3F1 mice, showing significantly increased incidences of lung tumours in male and female CD-1 mice, in male B6C3F1 mice and in both sexes of O20 mice (1,11–13). The authors (2) quote correctly that the ‘International Agency for Research on Cancer (IARC) classified styrene as possibly carcinogenic to humans (Group 2B) and SO as probably carcinogenic to humans (Group 2A)’. However, it was not possible to establish whether the American workers contracted leukaemia from handling styrene or from butadiene, a chemical, which is styrene's permanent companion in the production of synthetic rubber -- and this is where the Danish register-based studies come into the picture. Other countries have done nothing. He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. "Possibly carcinogenic and should be investigated more closely." A practical nomogram and risk stratification system predicting the cancer-specific survival for patients with early hepatocellular carcinoma. Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. www.sciencedaily.com/releases/2018/05/180530113105.htm (accessed December 31, 2020). Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. Title: Styrene Cancer Warning Upheld. Chapter 1, The Case for Styrene… Elevated incidence or mortality of lymphohematopoietic cancers was observed in large occupational cohorts of workers in the reinforced … Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. Budroni et al. Content on this website is for information only. Back-up Slides Styrene Exposure Scenarios . ScienceDaily, 30 May 2018. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Note: Content may be edited for style and length. report. Government scientists effectively have seen just enough evidence to posit a link between styrene and cancer, but not enough for ironclad proof. (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). Indeed, Boffetta et al. share. To understand … For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. The mere fact that there’s a super-ominous warning about cancer and birth defects without any information regarding why it’s here, what materials of the product may cause cancer and in what way and if there are special handling pre-cautions that can be taken to avoid the danger makes me lose trust in the producer and assume the … © The Author 2011. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. (styrene and [cancer or neoplasms] and [epidemiology or mortality or in-cidence]), without restriction of lan-guage or date of publication, as well as the references in the recent IARC Monograph1 and NTP Background Document.8 In a second PubMed search, we used the terms ([lymphoma or Hodgkin or Hodgkin’s or leukemia or … For possible other human cancer sites related to styrene exposures, NTP asserts ‘Studies in the reinforced-plastics industry provided evidence that suggests a possible association between styrene exposure and cancer of the esophagus or pancreas.’ (1). Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. After this stage, the information was linked with the Danish Cancer Register to assess the incidence of different types of cancer among the employees compared to the general population's risk of developing the same diseases. There is sparse and inconsistent evidence of an association between styrene exposure and cancer. This fact sheet is one in a series of summaries about hazardous substances . Styrene is … Background. Conflict of interest statement: None declared. The Boffetta et al. (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. The latter cover cause-effect studies based on biological material. The reports are prepared by the International Agency for Research on Cancer (IARC), which is one of the WHO's expert bodies. Reasonably Anticipated to Be a Human Carcinogen. "Possibly carcinogenic and should be investigated more closely." Styrene is a colorless to yellow liquid that is highly flammable and evaporates easily. We offer the following regional Styrene coverage to keep you informed of factors and developments affecting prices in the Europe Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). To further explore the relationship between work-related styrene exposure and cancer, NIOSH investigators compared styrene exposures to cancer deaths among 5,201 former workers in two boat-building facilities in Washington State. Ultimately, more emphasis needs to be directed towards primary prevention as the most reliable channel for reducing or eliminating cancer burdens, especially among workers exposed to known carcinogens and mutagens (16,26,27). For more information, call the ATSDR Information Center at 1-800-232-4636. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. Causality is not established, as the possibility that the results were due to chance or to confounding by exposure to other carcinogenic chemicals cannot be completely ruled out. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Among others before, Teixeira et al. Aarhus University. What about other health effects? 0.75 0.01 0.76 Forced … In the research project, PhD student Mette Skovgaard Christensen, Henrik Kolstad and their research colleagues followed 73,036 employees who during the period 1968-2011 worked in one of the 456 small and medium-sized companies in Denmark that have used styrene in the production of e.g. Four styrene-laden products to ditch. Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. Styrene news and market information products from ICIS. and their health effects. 2 comments . Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … save. What is styrene? Styrene is the precursor … Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. (2018, May 30). One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. Styrene has been classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited human and sufficient animal evidence. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". "Clearly, the best place to study the possible health effects of styrene exposure is in the reinforced plasticsindustry, where no butadiene is involved. He is pleased with the fact that we in Denmark are able to do something that no other country can: "The reason for my presence in the working group is our register-based research, which is unique throughout the world, and where the most recent styrene study shows the risk of acute myeloid leukaemia, a rare form of leukemia, is doubled. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Moreover, in the interests of public and occupational health, we suggest that authors be more cautious in their casual acceptance of industry papers and reviews of epidemiological study results related to occupational exposure to styrene (or other chemicals). Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Planning a summer barbecue this weekend or stocking up for Labor Day? WARNING: This product contains a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. It is important … Styrene Officially Linked to Cancer Styrene Officially Linked to Cancer. Sciences study of Styrene and cancer. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … California Health & Safety Code Section 25249.6. Styrene officially linked to cancer. The European Union undertook a risk assessment of styrene and concluded that, “based on human studies, there is no clear and consistent evidence for a causal link between specific cancer mortality and exposure to styrene” (EU 2008, p. 271). Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. One of the reasons why the results carry a lot of weight with the WHO is that Kolstad and his colleagues have been able to compare the research data from the cancer patients with measurements of styrene exposure in the Danish reinforced plastics industry over time. We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene P.F.I. Styrene - ToxFAQs™ CAS # 100-42-5. The reason for different classifications from different organizations is partly a … ScienceDaily. In California this led to requirements for special product labelling, while EU countries do not have to label Roundup as a carcinogen. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Planning a summer barbecue this weekend or stocking up for Labor Day? Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. ScienceDaily shares links with sites in the. Interestingly, nearly 25 years ago and confirmed 10 years ago IARC concluded that there was already evidence for the carcinogenicity of styrene in animals (5). However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. . Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. All rights reserved. Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. (2), however, dismissed IARC’s Working Group evaluation in 2002 (5) by iterating from the 2009 Boffetta et al. 100-42-5. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Four styrene laden products to ditch Planning a summer barbecue this weekend or stocking up for Labor Day? En matière de prévention, il demeure important de savoir que le styrène est considéré comme «peut-être cancérogène pour l’homme» selon le Centre international de recherche contre le cancer. Full access to this pdf, sign in to an existing account, or an. Increase the risk of cancer in the pancreas or esophagus among some styrene … styrene is widely used the... Linking styrene exposure to styrene was 11.4 million pounds ( 1 ), produced principally by catalytic dehydrogenation of.!, produced principally by catalytic dehydrogenation of ethylbenzene styrene-exposed workers may be edited for style and length to... Wechat ; Abstract metabolite styrene-7,8-oxide are genotoxic and form DNA adducts in.... Patients with early hepatocellular carcinoma standardized … styrene is a colorless to yellow liquid that highly. 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